I used mesquite on my pork ribs ...and it turned out great! Mesquite base-smoke with handfuls of hickory, apple and some cherry chips every half hour or so during the '3' of the 321 method. Good stuff. I tried it due to my family's reaction to the heavy hickory flavor I like and have been using. They appreciated what I'm assuming to be the smoother(?) flavor of the mesquite, not so heavy/tangy. 'Better than last time' my daughter said. I'm willing to take that one as a biggole thumbs up!!