Dave brings you sage advice. Hitting the proper degree marks during the process.
As I recall, the ovens I used when I was doing oven drying, typically ran pretty dang warm. 140°-170° (If the oven thermometers were to be believed) was typical.
Now I use a Presto Brand Dehydro
dehydrator I was given as a Christmas gift. I checked it and on it's highest setting of 165°, it actually is running at 173°. So I feel confident I'm making bug free jerky now days.
I don't reduce the temperature during my process. I set it, and forget it. Most recently I've been making Pork Loin jerky as a test, and I'm finding it very much to my liking over beef. Since it is a whole muscle meat, I'm using wet marinades and also vacuum marinading in the fridge overnight. Works for me.
I also use Cure #1 (Prague Powder) in my batches. I think it gives the meat a better flavor, and it is supposed to take care of any bugs. I use a struck off 1/4 tsp P/pound of meat.
Some think using cure is a bad thing, that it is bad for you. Most of the cure is neutralized by the heat, after it has done in the bacteria.
I don't question it, I just use it. And in my opinion I think it gives a little better taste. Based on forgetting it in some batches and noticing the jerky seem "blah". I don't know, maybe dead bacteria jerks better.... :confused:
No doubt you can hit the temperature marks using your smoker as a drying medium.
For ground beef jerky, part of the process in my dehydrators book sez to finish it in an oven at 250° for 10 minutes. It comes out sizzling, and tastes like over cooked hamburger to me. So I've gravitated back to whole muscle jerky.
Just my preference, all semantics aside.
The bottom line is, both my dog and I are still alive....;)