I just use Soap and Hot water...If Probe was clean on the first stick, exterior at 140*, you are not introducing any bacteria. The only time you need to have disinfecting wipes handy would be for multiple sticks using an Instant read, like in a Restaurant situation or to test IT of multiple meats at different stages of cooking. Considering you should not be punching holes in your meat anyway, by the time it becomes necessary to test for IT the meat is very nearly cooked and the IT would instantly kill anything that may be on the probe. Bottom line if you are really worried get them but outside of a restaurant I have never had to use them...JJ