I'm not sure. I have used it in my GOSM, but only at temps below 285. Even then the pellets burn at a faster rate. If you were doing a low temp 250 or less smoke, had you diffuser to separate the tube from the flames, and then another diffuser to keep stuff from dripping on the tube you probably could do it. You'd need to make sure the rack that the tube was on was no more than 285*. I suppose you could offset the tube to one side of the drum , and the meat to the other side to help keep the juices off.
A whole different approach would be to make a separate chamber for the tube and pipe the smoke in. The mailbox mod or something similar.