Welcome to the madness of smoking things!
This is how I do a brisket and it usually turns out pretty good.
I take it out of the cryo bag and rinse it off really well. Pat it dry with some paper towels, trim any fat that needs to be removed, slather it with some yellow mustard, and then coat it with a dry rub of choice. Hard to beat SPOG (Salt, Pepper, Onion powder, and Garlic powder).
Then into a 225-250 degree smoker until I get to a temp of around 195. At that point I begin to probe with a skewer to see how done it is. When the skewer goes in like a hot knife into butter, it's ready to pull out.
I then wrap it in foil and place it into a blanket inside of a dry cooler. Let it rest for at least an hour, then slice it up for some good eats!
Other will chime in soon with some more ideas.