Scientific evidence or opinion? Both...If any meat is going to have a high bacterial load it is ground beef, fact. If meat is cooked at temps below 200 degrees, depending on the weight and dimensions, the center of the meat can be in the prime region of the danger zone, 80-100, in excess of 4 hours. In these conditions some bacteria can double or triple their numbers in under 1 hour,fact. I rarely make meat loaves less than 4 pounds of meat plus add-ons. Thats a lot to handle, bag and wait to cook SV when an hour at 400 and we eat,fact and opinion. The point of sous vide is tenderizing meat and even cooking to a desired lT. Since neither of these greatly enhance a meatloaf and you don't get that great crunchy crust, spending the time to SV a meatloaf is pointless for me,opinion. As far as my words being absolute...l just give the facts mixed with opinion based on over 20 years cooking professionally responsible for thousands of people safety and never made anyone sick. Evaluate my credibility then choose to follow or ignore what l put out.
I did a lot of dumb stuff in my youth until l was educated on how risky it was. Drank heavily and drove, didn't wear a seatbelt until my mid twenties, defrosted meat on the counter overnight and all day and thought nothing of eating food that sat out overnight. I know better now and just share what l have learned over the years...JJ