So I did exactly this (smoke then sous vide) this past weekend. I smoked it for 2 hours at 250 (apple + cherry woods), then put it straight into the sous vide at 165.I ran into one significant issue - about 2 hours into the water, the seal on my bag failed! I happened to notice "too much" of a smell (a good smell, but not one you want from sous vide!) so I checked it, and sure enough, there was juice in the water. I pulled it out (lost all the juice that was in the bag), double-bagged it to be safe (double vacuum sealed), and added extra rub and honey to compensate for the presumed lost flavor from the seal snafu, replaced the water, and put it back in.
I pulled it from the sous vide after 17 total hours, and I was up against a time crunch and I had a brisket on my BGE, so I stuck it under the broiler to get a bark (worked quite well, actually).
Ultimately, the pork was still extremely juicy, but it wasn't as flavorful as expected, which I attribute to the compromised seal.
All in all, I'd do it again. I used a similar process on the brisket (without the seal issue!) and it was absolutely fantastic.