One goal is to try to keep the auger length at a minimum - keeps less pellets in the tube, less motor torque required, etc, so some have the firepot closer to the hopper. You would think a centered firepot would make temp more even, but there are grills with centered pots that have big variances, and those with offset pots that have less.
My preference is for grills that use a drop chute system. But again, some are centered and some offset.