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Good question although I doubt I would ever use it on a brisket. I tend to use rubs on those hunks of meat that can truly benefit from it and usually I scrape the fat cap off post cooking so I'd never eat it anyways. If I do anything to the exterior of a brisket it is simply salt and pepper after trimming the fat cap as I want that beef flavor to come through unmasked.
Now that the disclaimers are out, why not just use Jeff's current rub offering on the brisket?
Less get this straight right off the bat. A rub is a rub it can be used on everything that you smoke. Jeff's is a good rub and the stores are full of them. Now I use different rubs fro time to time. Right now I'm using a very simple rub. Old Bay and brown sugar mixture on everything. Now it's very tastey and it has a kick to it that IO like. I happen to like a little spice with my food. So use jeff's rub or just go to the store and pick one and if you don't like it change to a different one.
I was in a local smoke shop and bought some beef rub, it is called Obie Cues Texas Brisket Rub. I have never used it on a brisket but i was pleased with the outcome when i applied it to a chuck roast a couple of weeks ago . Pkerchef