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The danger zone... It's recommended 4 hours or less in that temp zone..
Cook in an elevated temperature so the meat warms fairly fast... recommended oven temp is 225 F and higher...
If you are using cure #1 in the meat, the danger zone doesn't apply...
Whenever you smoke meats, cure #1 is pretty much mandatory to prevent botulism poisoning...
Whole muscle meats are considered sterile on the inside so.. a high temp, at first, to kill surface bacteria is recommended.. as an example... I cook "some" prime rib at 450 for the first 10-15 minutes, then lower the temp to 200-225 and cook to 125-130 ish IT.. That gives the meat a nice bark without overcooking the interior..