First brisket (overnight)

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I will be doing my first bracket tomorrow, or should I be starting tonight?  It's a half brisket, weighs about 4 lbs and will be smoking on my MES with the amnps.  Can I start the brisket at 8 in the morning and have it ready by 5pm?  What is the internal temperature I want to reach?  I've been cautioned not to put liquid in the water pan, is that ok with a brisket?
 
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