For brisket 225* is typical and considered safe...high enough heat to pasteurize the surface. 110* isn't going to get the job done, and is not a safe smoking temp for a large cut of meat...unless it were for a short duration, then bumped up to ~250*. But then, if it will only smoke at lower temps and the brisket were only exposed to smoke for a short time there wouldn't be much point in smoking it.
If you can make your pellet tube do the job, use it, with your temp set @ 225* or a bit higher if desired. You my need to find out where it needs to be placed so cooker heat doesn't effect the pellet burn (high temps cause flare-ups of the pellets), and, where it gets sufficient air to allow the pellets to smolder and do their thing (produce smoke).
Eric