Technically no, but you will run into other issues...
What if your guru goes down or your fans die or you dont have power? Then you will need the air-inlets. I run mine on 2x 25CFM fans, and leave the dampeners closed, but when I had to part out for my boss's system, I was only running on 1 fan, and had to have some of my inlets open a little (not much, just enough).
Also, built your inlets on multiple sides of the smoker. That way it can get air from most wind directions, and not just 1 (a problem we had with my boss's smoker too).