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I guess for me, you will have to clarify the question...If it is about spices, it would have to be garlic, salt, pepper. But, it it is open to other food/drink as a compliment, that would be onions, mushrooms, merlot (or Cab/Merlot)!
you're right, guys - the answers look great so far, but some clarification would probably be necessary.
i am intending this question as a seasoning for beef. by seasoning, i mean in the form of herbs or spices to be applied to said beef for slow-smoke cooking - i suppose it could also mean anything else (such as liquid) that could be applied to the beef.
EVOO
Crushed Garlic
Onion Salt
...are my 3 favorites as a spice to apply
Sauted Sweet Yellow Onions
Melted Smoked Gouda Cheese OR Maytag Blue Cheese
...are my favorite "toppings" for beef. But more for a steak than a brisket.
Now for a brisket spices I like are
Paprika, Granulated Garlic, Onion Salt
Ditto Dude on all of these. If I could have a 4th it would be a bit of rosemary for the brisket (I know it's more traditionally a lamb spice, but I like it in small amounts for beef too).
I have to run with the pack and say:
kosher salt
fresh ground pepper (heavy dosage)
Grandulated garlic power
But really how can you stop with onion powder and creole spices.