Its sort of up to how smoky you want the thing. I've also found on my MES that if you're using chips in the tray (as opposed to an
AMNPS) that for some reason it seems to produce a stronger smoke flavor, I think cause of how hot it gets them smoking and that its just induction rather than an actual burning. Anyway, if I use the chip tray on the MES, I almost never do more than 2 refills which you usually need to do at each hour or so increment, but that's just cause I don't like way too much smokiness to Butts. (and by that I mean that I like a very noticeable smoke flavor, but not overpowering the flavor of the meat and rub)
That being said, when I use the
AMNPS, I just burn a full tube which goes for like 6-8 hours, so going along with what AL said, in those cases I do it up till the time I foil it at the stall. (I do foil on every butt, I get much better results that way personally).
Just try this one out, take some notes, and adjust in the future depending on how it turned out. Every time I have done my MES 30 with filling the chip tray more than 2-3 times the meat comes out way too smoky for my preference. The first smoke I did on my MES with chips I filled the entire cook, and didn't wrap, and the meat was just way over the top smoky.
Sorry for the overload of info, hope some of it helps/ Please take some pics, and let us know how it turned out!