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i always slice across the grain............easier to chew..........in my experience, if you cut with the grain, you just created dental floss.........
but thats me..........i am pretty sure there are some that slice WITH the grain, but i believe they also use a meat tenderizer before added the marinade/cure
also Jack..........cut the roast into managable pieces........put in freezer for 1/2 to 1 hour, depending on the size of the chunk........slices easier when the meat is firm