Sounds excellent!
By all means, smoke away! 165* internal finished temp will suffice, though I'd likely go to 170* myself. And, yes, the 40-140*/4-hr rule applies, being it's ground meat and also because it's stuffed.
Unless it's a large diameter fatty when prepped (4lbs or more), 225* smoke chamber/grate temps should do the job and get your internals up over 140* in plenty of time. I would suggest apple, or cherry, along with pecan for smoke, if you can get them. Hickory for a second choice (easy to find in most places), but use it sparingly as it is fairly sharp for poultry.
Let us know how it comes out, and don't forget to grab a couple pics for bragging rights!
Eric