However you like it.......My experience with ribs has been this: if I buy locally (fresh cut), they can get dried out quickly without foiling, even doing a wet smoke; if I buy from a chain store (enhanced) they can be much more forgiving to the smoker. And as stated earlier, yes, enhanced meat can change the flavor.
My own rib rubs were developed using enhanced meat, and when I smoked some fresh ribs...whooooaaaaaaaah!!!!!!!!!!! Had a bad flavor goin' there. You can make adjustments to your rubs/sauces to compensate for this, though it may take some trial and error. Also, smoke wood can make a huge difference.
Whether you choose fresh or enhanced, you need to find what works for you, and stick with it. If you're like me, you'll try anything once...twice if you like it!!!!!!!! LOL!!!
Also, the enhanced ribs have an added benefit of a long fridge life (for those spur of the moment/unplanned smokes), unless you buy them on a manger's special (clearance/must sell), in which case you will need to use/freeze them very soon.
Hope this helps a bit. It's just another one of those preference things.